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Your heart, brain, and immune system share the same DNA sequence. So how can a single-letter change affect disease in some cells, while sparing the rest? AlphaGenome 2 is our new AI model that zooms in on specific cells to help scientists understand what drives disease. 🧵

Google DeepMind · X· @GoogleDeepMind·· 1 day ago

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Google DeepMind
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unveils AlphaGenome 2, an AI model that predicts genetic variant effects across individual cell types and states
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AlphaGenome 2 is our new AI model that zooms in on specific cells to help scientists understand what drives disease.

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See the full storyGoogle DeepMind Releases AlphaGenome 2 for Cell-Specific Genetic Research

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    Article

    Your heart, brain, and immune system share the same DNA sequence. So how can a single-letter change affect disease in some cells, while sparing the rest?

    AlphaGenome 2 is our new AI model that zooms in on specific cells to help scientists understand what drives disease. 🧵

    The story so far

    Google DeepMind has released AlphaGenome 2, a model that predicts how DNA variants affect specific human cell types and states. The model is available through the AlphaGenome API for non-commercial research, while commercial research access is in a closed private preview. Google says it is intended for research and has not been validated or approved for clinical or diagnostic use. Google says AlphaGenome 2 was trained on more than 107 million cell profiles. On the TenK10K benchmark, it identified nearly twice as many causal variants as the original AlphaGenome; The Decoder reports about 30 percent for AlphaGenome 2 versus 16 percent for a fine-tuned AlphaGenome 1.

    How the story developed · 2

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    1. 11/12 00:02 (UTC+8)

      Your heart, brain, and immune system share the same DNA sequence. So how can a single-letter change affect disease in some cells, while sparing the rest? AlphaGenome 2 is our new AI model that zooms in on specific cells to help scientists understand what drives disease. 🧵 This report

    2. 11/11 23:20 (UTC+8)
      Google DeepMind Announces AlphaGenome 2 for Cell-Specific DNA Variant PredictionGoogle DeepMind